After Ashley Stone tied it for SU (7-9, 3-4 ODAC) at 24-24 on a free throw with 4:54 to play in the second, VWU scored the game's next 15 points to take a lead it would not relinquish over the Hornets.
The Marlins (6-10, 3-4) started the run with a 3-pointer and scored the final seven points of the first half to take a 33-26 lead into the break.
The second half brought more of the same, with another 3-pointer to start the third, and VWU eventually expanded the lead out to 15-points before Kirstyn Arcata had a layup in the paint with 4:53 remaining in the stanza.
Unfortunately for the Hornets, Virginia Wesleyan would hold at least a seven-point lead the remainder of the contest.
A 17-7 Shenandoah run brought the Hornets to within seven, 56-49, with 2:32 left, but the Marlins answered with a 14-8 closing run to provide the final margin of victory.
Stone led SU with a game-high 24 points while Arcata added 12. Arcata is now 28 points from the 1000-point mark for her career.
Virginia Wesleyan shot 47 percent (23-of-49) to 34 percent (19-of-56) for the Hornets and also had a 38-29 edge on the glass.
SU did score 14 of the game's 22 points off of turnovers and 13 of 15 second chance points.