The Royals (9-4, 4-1) scored nine straight points and ended the half on a 9-2 run to seize control of the contest.
EMU started the second half with another run, this one 10-1 over the initial 4:27, and never saw its lead dip below 14 points the rest of the way.
Trailing by 23, SU had a 7-0 run over a span of 2:49 that stretched over the end of the third quarter, but could get no closer.
Eastern Mennonite had a 42-29 advantage on the glass that led to a 16-2 advantage in second chance points.
The Royals also scored all 21 of the bench points in the game.
Senior Kirstyn Arcata paced the hosts with 15 points and is now 55 points from 1000 for her career.
Jess Washington had 15 points and 14 rebounds for the victors.