Shenandoah (13-6, 4-3 ODAC) banged out 20+ plus hits for the second straight day in taking out the Quakers (10-12-1, 1-6).
Nussman had a home run, a two-run shot in the ninth and his first of the season, with Smallwood driving in three runs.
Smallwood's second RBI, on a two-run double down the right field line in the fifth, proved to the game-winner.
SU scored four runs in the second, six in the fifth, two in the sixth, one in the seventh and three more in the eighth to pull away.
The offense was more than enough for senior Colin Morse, who tossed the first seven innings of the win. Morse (3-2) allowed two runs on four hits and one walk while striking out four.
Trevor Denton (3-4) took the loss after giving up eight runs on 11 hits and three walks in 4.0 innings.
The two teams complete their weekend series with a 1 p.m. game Saturday.