Shenandoah (3-1, 1-0 ODAC) scored five of the game's initial six goals and never looked back against LC (3-3, 1-1).
With SU holding its biggest lead, nine goals, following a Samantha Donaghy goal with 16:42 remaining, LC made matters interesting by scoring five of the next six goals of the game to cut the deficit to five with 3:41 left.
Donaghy then clinched it for the hosts with an unassisted goal 60 seconds later to push the margin back to six.
The nine-goal advantage was actually the second time that coach Lindsey Lutz' club led by that amount – a 5-0 Shenandoah run in the last 7:21 of the first half makde it 13-4 at the break.
Lynchburg opened the second with goals at 28:33 and 26:54 to keep its hopes alive, but Corrinne Kosmowski and then Donaghy answered to keep the momentum on the home side.
Sisson had five of her six goals and her lone assist in the first half as SU took 21 of 31 shots in the half and won 12 of 18 draws.
Shenandoah also forced six Lynchburg turnovers in the opening stanza while committing just two of its own.
SU goalkeeper Ashley Cross made eight of her 11 saves in the second half.
LC's Kendall Adkin matched Sisson with six goals and one assist.
Shenandoah hosts Hope on Monday in a non-conference contest.