Shenandoah (8-11, 5-7 USA South) led virtually throughout the contest, but could never quite put MBC (4-12, 2-10) away.
Playing without leading scorer Sabrina Desper, the Squirrels took advantage of a poor shooting night by SU (9 of 27 in the first half) and 22 turnovers to stay within five points for the majority of the second half.
Fortunately for the home fans, Shenandoah turned a 47-41 lead with 4:51 to play into the 16-point win by outscoring Mary Baldwin 15-5 over the final 4:13.
SU missed just one shot from the field during this final run and sophomore Sara D'Amico had two of her game-high six 3-pointers as the Hornets pulled away down the stretch.
D'Amico set a herself a new career-high in points with 22 as she was 6 of 9 from the field (6 for 6 from behind the arc) and made 4 of 6 from the line.
D'Amico's 22 points in a reserve role helped Shenandoah to a 43-2 advantage in bench scoring Tuesday evening.
The Squirrels, who played just seven players, had 17 points from Shanice Miles and 12 from Meagan Barron.
The victory is the 11th straight for SU over its soon-to-be former conference rival.
Shenandoah is back in action on Saturday at Methodist in a 2:00 USA South Conference contest.